Etomoxir((R)-(+)-Etomoxir) 钠盐是肉碱棕榈酰转移酶 1a (CPT-1a) 的不可逆抑制剂，通过 CPT-1a 抑制脂肪酸氧化 (FAO) 并抑制棕榈酸盐 β-在人、大鼠中的氧化和豚鼠。
| Cas No. | 828934-41-4 |
| 别名 | (R)-(+)-乙莫克舍钠盐,(R)-(+)-Etomoxir sodium salt |
| 化学名 | sodium (R)-2-(6-(4-chlorophenoxy)hexyl)oxirane-2-carboxylate |
| Canonical SMILES | ClC1=CC=C(C=C1)OCCCCCC[C@@]2(C([O-])=O)OC2.[Na+] |
| 分子式 | C15H18ClNaO4 |
| 分子量 | 320.74 |
| 溶解度 | ≥ 12mg/mL in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Etomoxir sodium salt ((R)-(+)-Etomoxir sodium salt) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig. References:
[1]. Agius L, et al. Differences between human, rat and guinea pig hepatocyte cultures. A comparative study of their rates of beta-oxidation and esterification of palmitate and their sensitivity to R-etomoxir. Biochem Pharmacol. 1991 Oct 9;42(9):1711-5.
[2]. O'Connor RS, et al. The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations. Sci Rep. 2018 Apr 19;8(1):6289. |
