4-Ethynyl-L-phenylalanine hydrochloride

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CAS NO:

188640-63-3

包装与价格：

4-Ethynyl-L-phenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) 是一种有效的、选择性的、可逆的和竞争性的色氨酸羟化酶 (TPH) 抑制剂，Ki 为 32.6 μM.

Cas No.	188640-63-3
别名	4-Ethynyl-L-phenylalanine hydrochloride
Canonical SMILES	N[C@@H](CC1=CC=C(C#C)C=C1)C(O)=O.[H]Cl
分子式	C₁₁H₁₂ClNO₂
分子量	225.67
溶解度	Methanol: 125 mg/mL (553.91 mM); DMSO: 100 mg/mL (443.12 mM); Water:< 0.1 mg/mL (insoluble)
储存条件	Store at -20℃
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	4-Ethynyl-L-phenylalanine hydrochloride is a selective, reversible, potent and competitive inhibitor of tryptophan hydroxylase (TPH). 4-Ethynyl-L-phenylalanine hydrochloride is a competitive inhibitor with regard to the substrate tryptophan, with a Ki of 32.6 μM. 4-Ethynyl-L-phenylalanine hydrochloride selectively and reversibly inhibits the biosynthesis of serotonin[1]. 4-Ethynyl-L-phenylalanine hydrochloride (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue[1].4-Ethynyl-L-phenylalanine hydrochloride is not inhibiting the aromatic amino acid decarboxylase[1].4-Ethynyl-L-phenylalanine hydrochloride has a low affinity for various recombinant 5-HT receptors[1]. Animal Model: Male Sprague-Dawley rats (200 g)[1] [1]. Stokes AH, et al. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. J Neurochem. 2000 May;74(5):2067-73.