Palmatine 是一种口服活性的不可逆 IDO-1 抑制剂。Palmatine 可以减轻结肠损伤，预防肠道菌群失调和调节色氨酸分解代谢，从而改善DSS诱发的结肠炎。Palmatine 具有治疗结肠炎的潜力。
| Cas No. | 3486-67-7 |
| 别名 | 黄藤素 |
| Canonical SMILES | COC1=C(OC)C2=C[N+]3=C(C4=CC(OC)=C(OC)C=C4CC3)C=C2C=C1 |
| 分子式 | C21H22NO4+ |
| 分子量 | 352.4 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. Palmatine can ameliorate DSS-induced colitis by mitigating colonic injury, preventing gut microbiota dysbiosis, and regulating tryptophan catabolism. Palmatine has the potential for colitis treatment[1]. [1]. Zhang XJ, et al. Palmatine ameliorated murine colitis by suppressing tryptophan metabolism and regulating gut microbiota.Pharmacol Res. 2018 Nov;137:34-46. |
