Nrf2-IN-1 (Compound 4f) 是 Nrf2 的抑制剂，具有作为治疗急性髓性白血病 (AML) 药物的前景。
| Cas No. | 1610022-76-8 |
| Canonical SMILES | O=C(NO)C1=CC(C2=CC=C(Cl)C=C2)=NN1CC3=CC=C(C(C)(C)C)C=C3 |
| 分子式 | C21H22ClN3O2 |
| 分子量 | 383.87 |
| 溶解度 | DMSO: 260 mg/mL (677.31 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Nrf2-IN-1 (Compound 4f) is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2), acts as a promising agent in acute myeloid leukemia (AML) therapy[1].
Nrf2[1] [1]. Zhang J, et al. Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells. Oncotarget. 2017 Jan 31;8(5):7625-7636. |
