SID 3712249 (MiR-544 Inhibitor 1) (MiR-544 Inhibitor 1) 是一种 miR-544 生物发生抑制剂。 SID 3712249（MiR-544 Inhibitor 1）直接与前体 miRNA 结合。 SID 3712249 (MiR-544 Inhibitor 1) 阻断成熟 microRNA 的产生并减少 miR-544、HIF-1⋱ 和 ATM 转录物。 SID 3712249 (MiR-544 Inhibitor 1) 可用于癌症研究，例如乳腺癌。
| Cas No. | 522606-67-3 |
| 别名 | MiR-544 Inhibitor 1 |
| Canonical SMILES | NC1=C2C(C=C(N3CCCC3)N=C2N)=C(C#N)C(N4CCCC4)=N1 |
| 分子式 | C17H21N7 |
| 分子量 | 323.4 |
| 溶解度 | DMSO : ≥ 30 mg/mL (92.76 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). Target: MiR-544MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantion into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2′-O-methyl RNA antagomir. [1]. Zhi Q, et al. Oncogenic miR-544 is an important molecular target in gastric cancer. Anticancer Agents Med Chem. 2013 Feb;13(2):270-5. |
