Amicoumacin B is an amicoumacin that has been found inN. jinanensisand has quorum-sensing inhibitory activity.¹It is active againstC. violaceum(MIC = 250 µg/ml) and reduces the expression of theC. violaceumoperonsvioA,vioB,vioD, andvioE, but increases the expression ofvioC, indicating quorum sensing inhibitory activity.²Amicoumacin B increases the expression of bone morphogenetic protein 2 (BMP2) in MG-63 cells.^1,3

1.Sun, W., Zhang, Y.-Q., Huang, Y., et al.Nocardia jinanensis sp. nov., an amicoumacin B-producing actinomyceteInt. J. Syst. Evol. Microbiol.59(Pt 2)417-420(2009) 2.Shi, W.-P., Zeng, H., Wan, C.-X., et al.Amicoumacins from a desert bacterium: quorum sensing inhibitor against Chromobacterium violaceumNat. Prod. Res.(2020) 3.Zhao-Yong, Y., Zhi-Fei, Z., Xiao-Bo, H., et al.Study on the effect of amicoumacin B on up-regulating bmp-2 transcription and expression in MG63 cellsChin. J. Antibiot.33(4)203-205(2008)