2′-Deoxy-2′-fluoroguanosine，一种核苷类似物，是有效的流感病毒 (influenza virus) 抑制剂，抑制 A 型和 B 型流感病毒的 EC90 值<0.35 µM。2′-Deoxy-2′-fluoroguanosine 可显着抑制流感病毒在上呼吸道中的复制，从而改善发烧和鼻腔炎症。
| Cas No. | 78842-13-4 |
| 别名 | 2'-脱氧-2'-氟鸟苷；2'-氟脱氧鸟苷；2'-氟-2'-脱氧鸟苷 |
| Canonical SMILES | O=C1C2=C(NC(N)=N1)N([C@]3([H])O[C@@H]([C@H]([C@H]3F)O)CO)C=N2 |
| 分子式 | C10H12FN5O4 |
| 分子量 | 285.23 |
| 溶解度 | DMSO : 50 mg/mL (175.30 mM) |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 2′-Deoxy-2′-fluoroguanosine, a nucleoside analog, is a potent inhibitor of influenza virus strains, with an EC90 of<0.35 µM for influenza virus A and B strains. 2′-Deoxy-2′-fluoroguanosine significantly inhibits replication of influenza virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation[1][2]. References:
[1]. Tisdale M, et, al. Inhibition of influenza virus transcription by 2'-deoxy-2'-fluoroguanosine. Antimicrob Agents Chemother. 1995 Nov;39(11):2454-8.
[2]. Jakeman KJ, et, al. Efficacy of 2'-deoxy-2'-fluororibosides against influenza A and B viruses in ferrets. Antimicrob Agents Chemother. 1994 Aug;38(8):1864-7. |
