DHODH-IN-5 是一种有效的人二氢硼酸脱氢酶 (DHODH) 抑制剂，人重组 DHODH 的pIC50 为 7.8。DHODH-IN-5 抑制麻疹病毒复制，pMIC50 为 8.8。
| Cas No. | 1644156-56-8 |
| Canonical SMILES | OC(C1=CC=CC=C1)C2=C(C)N(C3=NC=C(C4CC4)C=N3)N=C2OC(C)C |
| 分子式 | C21H24N4O2 |
| 分子量 | 364.44 |
| 溶解度 | DMSO: 125 mg/mL (342.99 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | DHODH-IN-5 is a potent human dihydroorotate dehydrogenase (DHODH) inhibitor, with a pIC50 of 7.8 for human recombinant DHODH. DHODH-IN-5 inhibits measles virus replication, with a pMIC50 of 8.8[1]. [1]. Munier-Lehmann H, et al. Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH). J Med Chem. 2015 Jan 22;58(2):860-77. |
