SAR125844是一种有效的、高度选择性的、可逆的、ATP竞争性的MET受体酪氨酸激酶(RTK)的静脉给药抑制剂，其IC50值为4.2nM。能抑制细胞中MET的自磷酸化。
| Cas No. | 1116743-46-4 |
| Canonical SMILES | O=C(NCCN1CCOCC1)NC2=NC3=CC=C(SC4=NN=C5C=CC(C6=CC=C(F)C=C6)=NN54)C=C3S2 |
| 分子式 | C25H23FN8O2S2 |
| 分子量 | 550.63 |
| 溶解度 | DMSO : 45 mg/mL (81.72 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | SAR125844 is a potent, highly selective, reversible and ATP-competitive MET receptor tyrosine kinase (RTK) inhibitor for intravenous administration, with an IC50 of 4.2 nM. Shows inhibition of MET autophosphorylation in cell-based assays[1]. [1]. Egile C, et al. The selective intravenous inhibitor of the MET tyrosine kinase SAR125844 inhibits tumor growth in MET-amplified cancer. Mol Cancer Ther. 2015 Feb;14(2):384-94. |
