BI-4464是具有高度选择性的，ATP竞争性的、PTK2/FAK的抑制剂，其IC50值为17nM。是可用于PROTAC降解剂的一个PTK2配体。
| Cas No. | 1227948-02-8 |
| Canonical SMILES | O=C(NC1CCN(C)CC1)C2=CC=C(NC3=NC=C(C(F)(F)F)C(OC4=CC=CC(CC5)=C4C5=O)=N3)C(OC)=C2 |
| 分子式 | C28H28F3N5O4 |
| 分子量 | 555.55 |
| 溶解度 | DMSO : 16.67 mg/mL (30.01 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC[1].
IC50: 17 nM (PTK2/FAK)[1]. [1]. Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520. |
