2-氟腺嘌呤是一种有毒的嘌呤碱基。 2-氟腺嘌呤对非增殖性和增殖性肿瘤细胞具有毒性。 2-氟腺嘌呤可用于抗癌研究。
| Cas No. | 700-49-2 |
| 别名 | 2-氟-6-氨基嘌呤 |
| Canonical SMILES | NC1=C2C(N=CN2)=NC(F)=N1 |
| 分子式 | C5H4FN5 |
| 分子量 | 153.1 |
| 溶解度 | DMSO: slightly soluble,Ethanol: slightly soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 2-Fluoroadenine is a heterocyclic building block that has been used in the synthesis of heat shock protein 90 (Hsp90) inhibitors that have anticancer activityin vitro.1It is also cytotoxic to CEM human leukemia cells with an IC50value of 0.15 µM.2 1.Llauger, L., He, H., Kim, J., et al.Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90J. Med. Chem.48(8)2892-2905(2005)
2.Parker, W.B., Allan, P.W., Shaddix, S.C., et al.Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cellsBiochem. Pharmacol.55(10)1673-1681(1998) |
