Mexiletine D6 hydrochloride (KOE-1173 D6 hydrochloride) 是 Mexiletine hydrochloride (KOE-1173 hydrochloride) 的氘代物。Mexiletine hydrochloride，一种 Class IB 类抗心律失常化合物，是钠离子通道 (voltage-gated sodium channel) 阻断剂。
| Cas No. | 1329835-60-0 |
| 别名 | 美西律-D6,KOE-1173-d6 hydrochloride |
| Canonical SMILES | CC1=CC=CC(C)=C1OC([2H])([2H])C(N)([2H])C([2H])([2H])[2H].[H]Cl |
| 分子式 | C11H12D6ClNO |
| 分子量 | 221.76 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Mexiletine D6 hydrochloride (KOE-1173 D6 hydrochloride) is a deuterium labeled Mexiletine hydrochloride (KOE-1173 hydrochloride). Mexiletine hydrochloride, a Class IB antianhythmic, is a non-selective voltage-gated sodium channel blocker[1]. [1]. Mori K, et al. Inhibitory effects of class I and IV antiarrhythmic drugs on the Na+-activated K+ channel current in guinea pig ventricular cells. Naunyn Schmiedebergs Arch Pharmacol. 1998 Dec;358(6):641-8. |
