SL 0101-1 (SL0101) 是一种山柰酚糖苷，从热带植物 F. refracta 中分离得到，是一种可渗透细胞的、选择性的、可逆的、ATP 竞争性的 p90 核糖体 S6 激酶 (RSK) 抑制剂，IC50 为 89 nM。 SL 0101-1 (SL0101) 是一种选择性 RSK1/2 抑制剂，Ki 为 1 μM。
| Cas No. | 77307-50-7 |
| 别名 | 3'',4''-二-O-乙酰基阿福豆苷,SL0101 |
| 化学名 | (2S,3S,4S,5R,6S)-6-((5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl)oxy)-5-hydroxy-2-methyltetrahydro-2H-pyran-3,4-diyl diacetate |
| Canonical SMILES | C[C@@]1([H])[C@@](OC(C)=O)([H])[C@](OC(C)=O)([H])[C@](O)([H])[C@@](OC(C(C2=C(O)C=C(O)C=C2O3)=O)=C3C4=CC=C(O)C=C4)([H])O1 |
| 分子式 | C25H24O12 |
| 分子量 | 516.46 |
| 溶解度 | DMF: 0.33 mg/ml,DMSO: 0.16 mg/ml |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC50 of 89 nM. Shows proliferation inhibition in human breast cancer cell line MCF-7 and produces a cell cycle block in G1 phase[1]. References:
[1]. Smith JA, et al. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res. 2005 Feb 1;65(3):1027-34. |
