KRAS G12D inhibitor 1 (example 243) 是 KRAS G12D 的抑制剂,其对KRAS G12D 介导的 ERK 磷酸化的 IC50 值为0.8 nM。
Cas No. | 2621928-43-4 |
分子式 | C33H32F2N6O2 |
分子量 | 582.64 |
溶解度 | DMSO : 55 mg/mL (94.40 mM; Need ultrasonic) |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | KRAS G12D inhibitor 1 (example 243) is a KRAS G12D inhibitor, with an IC50 of 0.8 nM for KRAS G12D-mediated ERK phosphorylation[1]. [1]. WANG XIAOLUN (US), et al. KRAS G12D INHIBITORS. WO2021041671. |