MNS (NSC 170724) 是一种 β-硝基苯乙烯衍生物，是一种有效的酪氨酸激酶抑制剂和广谱抗血小板剂。 MNS 完全抑制 U46619、ADP、花生四烯酸、胶原蛋白和凝血酶诱导的血小板聚集，IC50 值分别为 2.1、4.1、5.8、7.0 和 12.7 μM。 MNS 抑制 Src、Syk 和 FAK，IC50 分别为 27.3、2.8 和 97.6 μM。
| Cas No. | 1485-00-3 |
| 别名 | 3,4-亚甲二氧-beta-硝基苯乙烯,NSC 170724; 5-(2-Nitrovinyl)benzodioxole |
| 化学名 | 5-[(E)-2-nitroethenyl]-1,3-benzodioxole |
| Canonical SMILES | C1OC2=C(O1)C=C(C=C2)C=C[N+](=O)[O-] |
| 分子式 | C9H7NO4 |
| 分子量 | 193.16 |
| 溶解度 | ≥ 8mg/mL in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | MNS is a potent and selective inhibitor of Src and Syk tyrosine kinases. target: src, syk. [1]IC50:29.3 (src), 2.5 uM (syk); [1]In vitro: no direct effects on protein kinase C, Ca2+ mobilization, Ca2+-dependent enzymes, PKC activation. MNS potently prevents GPIIb/IIIa activation and platelet aggregation without directly affecting other signaling pathways required for platelet activation. [1] [2] MNS is much more potent than genistein in inhibiting platelet aggregation and protein tyrosine phosphorylation. [2] References:
[1]. Wang WY et al. Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-beta-nitrostyrene, a novel tyrosinekinase inhibitor. Mol Pharmacol. 2006 Oct;70(4):1380-9.
[2]. Wang WY et al. Synthesis and pharmacological evaluation of novel beta-nitrostyrene derivatives as tyrosine kinase inhibitorswith potent antiplatelet activity. Biochem Pharmacol. 2007 Aug 15;74(4):601-11. |
