GDC-0077 (RG6114) 是一种有效的、可口服的、选择性的 PI3Kα；抑制剂（IC50=0.038 nM）。 GDC-0077 (RG6114) 通过与 PI3K 的 ATP 结合位点结合发挥其活性，从而抑制 PIP2 磷酸化为 PIP3。 GDC-0077 (RG6114) 对突变型与野生型 PI3Kα 相比更具选择性；。
| Cas No. | 2060571-02-8 |
| 别名 | GDC-0077; RG6114 |
| Canonical SMILES | C[C@@H](C(N)=O)NC1=CC=C(C2=NC(N3[C@H](C(F)F)COC3=O)=CN2CCO4)C4=C1 |
| 分子式 | C18H19F2N5O4 |
| 分子量 | 407.37 |
| 溶解度 | DMSO : ≥ 180 mg/mL (441.86 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | GDC-0077 is an orally available PI3K inhibitor with potential antineoplastic activity. GDC-0077 is extracted from patent WO 2017001645 A1, formula I. [1]. WO 2017001645 A1 |
