GNE-3511 是一种具有口服活性的生物利用度和脑渗透性双亮氨酸拉链激酶 (DLK) 抑制剂，Ki 为 0.5 nM。
| Cas No. | 1496581-76-0 |
| Canonical SMILES | N#CC1=CC=NC(NC2=NC(N3CC(F)(F)CC3)=CC(C4CCN(C5COC5)CC4)=C2)=C1 |
| 分子式 | C23H26F2N6O |
| 分子量 | 440.49 |
| 溶解度 | DMSO : ≥ 32 mg/mL (72.65 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | GNE-3511 is a dual leucine zipper kinase (DLK) inhibitor with a Ki of 0.5 nM. References:
[1]. Patel S et al. Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models. J Med Chem. 2015 Jan 8;58(1):401-18. |
