OXFBD04 是一种有效的选择性 BRD4 抑制剂，IC50 为 166 nM。OXFBD04 是一种有效的 BET 溴结构域配体，对 CREBBP 溴结构域具有额外的适度亲和力。OXFBD04 具有抗癌活性。
| Cas No. | 2231747-03-6 |
| Canonical SMILES | OC(C1=CC(O)=CC(C2=C(C)ON=C2C)=C1)C3=CC=CN=C3 |
| 分子式 | C17H16N2O3 |
| 分子量 | 296.32 |
| 溶解度 | DMSO: ≥ 250 mg/mL (843.68 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | OXFBD04 is a potent and selective BRD4 inhibitor with an IC50 of 166?nM. OXFBD04 is a potent BET bromodomain ligand with additional modest affinity for the CREBBP bromodomain. OXFBD04 has anti-cancer activity[1]. [1]. Jennings LE, et al. BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability. Bioorg Med Chem. 2018 Jul 15;26(11):2937-2957. |
