(E)-Methyl4-coumarate(Methyl4-hydroxycinnamate)在几种植物中发现，如葱(Alliumcepa)或noni(MorindacitrifoliaL.)叶中。(E)-Methyl4-coumarate与CarnosicAcid联用可诱导细胞凋亡，杀死急性髓性白血病细胞，但不能杀死正常的外周血单核细胞。(E)-Methyl4-coumarate具有抗氧化和抗菌活性。
| Cas No. | 19367-38-5 |
| 别名 | 4-羟基肉桂酸甲酯; Methyl trans-p-coumarate |
| Canonical SMILES | O=C(OC)/C=C/C1=CC=C(O)C=C1.[E] |
| 分子式 | C10H10O3 |
| 分子量 | 178.18 |
| 溶解度 | DMSO: 100 mg/mL (561.23 mM) |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | (E)-Methyl 4-coumarate (Methyl 4-hydroxycinnamate), found in several plants, such as green onion (Allium cepa) or noni (Morinda citrifolia L.) leaves. (E)-Methyl 4-coumarate cooperates with Carnosic Acid in inducing apoptosis and killing acute myeloid leukemia cells, but not normal peripheral blood mononuclear cells. Antioxidant and antimicrobial activity. [1]. Trachtenberg A, et al. Synergistic Cytotoxicity of Methyl 4-Hydroxycinnamate and Carnosic Acid to Acute Myeloid Leukemia Cells via Calcium-Dependent Apoptosis Induction. Front Pharmacol. 2019 May 9;10:507. |
