AXC-715 (T785) trihydrochloride 是一种 TLR7/TLR8 双激动剂，从专利 WO2020168017 A1 中获得。AXC-715 trihydrochloride 可用于合成抗体佐剂免疫偶联物，偶联物包括一个与程序性死亡配体 1 (PD-L1) 连接到一个或多个佐剂的抗体结构上。
| Cas No. | 2479276-17-8 |
| 别名 | T785 trihydrochloride |
| 分子式 | C18H28Cl3N5 |
| 分子量 | 420.81 |
| 溶解度 | DMSO : 125 mg/mL (297.05 mM; Need ultrasonic) |
| 储存条件 | 4°C, away from moisture |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | AXC-715 (T785) trihydrochloride is a TLR7/TLR8 dual agonist, extracted from patent WO2020168017 A1[1]. AXC-715 trihydrochloride, compound D from WO2020190734A1, can be used for synthesis of antibody-adjuvant immunoconjugates, comprising an antibody construct that binds programmed death-ligand 1 (PD-L1) linked to one or more adjuvants[2]. [1]. Sung-Ju Moon, et al. Compositions containing, methods and uses of antibody-tlr agonist conjugates. Patent WO2020168017A1.
[2]. Shelley Erin ACKERMAN, et al. Immunoconjugates targeting pd-l1. Patent WO2020190734A1. |
