(rac)-PF-998425 是一种有效、选择性的非甾体雄激素受体 (AR) 拮抗剂。(rac)-PF-998425 在 AR 结合和细胞分析中的 IC50 值分别为 26 和 90 nM。(rac)-PF-998425 具有用于研究雄激素性脱发的潜力。
| Cas No. | 1076225-26-7 |
| 分子式 | C14H14F3NO |
| 分子量 | 269.26 |
| 溶解度 | DMSO : 100 mg/mL (371.39 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | (rac)-PF-998425 is a potent, selective, nonsteroidal androgen receptor (AR) antagonist. (rac)-PF-998425 has IC50 values of 26 and 90 nM in the AR binding and cellular assays, respectively. (rac)-PF-998425 has the potential for the research of the androgenetic alopecia[1]. [1]. Li JJ, et al. Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. J Med Chem. 2008;51(21):7010-7014. |
