AGI-43192 是一种有效的蛋氨酸腺苷转移酶 2A (MAT2A) 抑制剂。AGI-43192 是一种有效但有限的脑渗透化合物。AGI-43192 具有探索 SAM 调节在中枢神经系统 (CNS) 中的作用和癌症疾病研究的潜力。
| Cas No. | 2377491-54-6 |
| 分子式 | C23H16ClF3N6O |
| 分子量 | 484.86 |
| 溶解度 | DMSO : 83.33 mg/mL (171.86 mM; ultrasonic and warming and heat to 60℃) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | AGI-43192 is a potent inhibitor of methionine adenosyltransferase 2A (MAT2A). AGI-43192 is a potent, but limited brain-penetrant compound. AGI-43192 has the potential for exploring the effects of SAM modulation in the central nervous system (CNS) and research of cancer disease[1]. [1]. Li M, et al. Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads. J Med Chem. 2022;65(6):4600-4615. |
