10,11-dehydro Curvularin 是一种流行的真菌植物毒素和抗生素。
| Cas No. | 21178-57-4 |
| 别名 | α,β-dehydro Curvularin |
| 化学名 | (4S,8E)-4,5,6,7-tetrahydro-11,13-dihydroxy-4-methyl-2H-3-benzoxacyclododecin-2,10(1H)-dione |
| Canonical SMILES | O=C1CC2=C(C(/C=C/CCC[C@H](C)O1)=O)C(O)=CC(O)=C2 |
| 分子式 | C16H18O5 |
| 分子量 | 290.3 |
| 溶解度 | 30mg/mL in DMSO, 30mg/mL in DMF, 10mg/mL in Ethanol |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 10,11-Dehydrocurvularin is an antibiotic and a strong activator of the heat shock response, a conserved evolutionary mechanism that maintains protein homeostasis via the overexpression of heat shock factor 1 (HSF1) and various chaperones including heat shock protein 90 (Hsp90). 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity[1][2]. References:
[1]. Xu Y, et al. Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus. Appl Environ Microbiol. 2013 Mar;79(6):2038-47.
[2]. Cochrane RV, et al. Comparison of 10,11-Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs. Chembiochem. 2015 Nov;16(17):2479-83. |
