ROCK inhibitor-2 是一种选择性 ROCK1 和 ROCK2 双抑制剂，IC50 值分别为 17 nM 和2 nM。
| Cas No. | 1127308-52-4 |
| Canonical SMILES | O=C(N[C@H](C)C1=CC=CC(OC)=C1)C(C=C2)=CC=C2C3=CC=NC=C3 |
| 分子式 | C21H20N2O2 |
| 分子量 | 332.4 |
| 溶解度 | DMSO: 250 mg/mL (752.11 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | ROCK inhibitor-2 is a selective dual ROCK1 and ROCK2 inhibitor with IC50s of 17 nM and 2 nM, respectively[1].
ROCK1|17 nM (IC50)|ROCK2|2 nM (IC50) [1]. Hobson AD, et al. Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based DrugDesign. J Med Chem. 2018 Dec 27;61(24):11074-11100. |
