TX1-85-1是一种Her3(ErbB3)抑制剂，IC50值为23nM。TX1-85-1可诱发Her3蛋白的部分降解并减弱Her3依赖性信号传导。
| Cas No. | 1603845-32-4 |
| Canonical SMILES | CC(N1CCN(C2CCC(N3N=C(C4=CC(NC(C=C)=O)=C(OC5=CC=CC=C5)C=C4)C6=C3N=CN=C6N)CC2)CC1)=O |
| 分子式 | C32H36N8O3 |
| 分子量 | 580.68 |
| 溶解度 | DMSO: 3.85 mg/mL (6.63 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | TX1-85-1 is a Her3 (ErbB3) inhibitor with an IC50 of 23 nM. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling[1].
ErbB3|23 nM (IC50) [1]. Xie T, et al. Pharmacological targeting of the pseudokinase Her3. Nat Chem Biol. 2014 Dec;10(12):1006-12. |
