VX-984 (M9831) (M9831) 是一种具有口服活性、强效、选择性和 BBB 穿透的 DNA-PK 抑制剂。 VX-984 (M9831) 有效抑制 NHEJ（非同源末端连接）并增加 DSB（DNA 双链断裂）。 VX-984 (M9831) 可用于胶质母细胞瘤 (GBM) 和非小细胞肺癌 (NSCLC) 研究。
| Cas No. | 1476074-39-1 |
| 别名 | M9831 |
| Canonical SMILES | O=C(C1=CC=NC2=C([C@H](C)CNC3=CC(C4=C([2H])N=C(C)N=C4[2H])=NC=N3)C=CC=C12)NC |
| 分子式 | C23H21D2N7O |
| 分子量 | 415.49 |
| 溶解度 | DMSO : 8.33 mg/mL (20.05 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | VX-984 is a potent DNA-PK inhibitor. [1]. By Charifson, Paul S; et al. DNA-PK inhibitors, US 20130281431 A1 |
