PKR-IN-C51(compound 51) 是一种 ATP 竞争性双链 RNA 活化蛋白激酶 (PKR) 抑制剂，IC50IC50 为 9 μM。PKR-IN-C51 在原代小鼠巨噬细胞中以剂量依赖性方式抑制细胞内 PKR 活化。
| Cas No. | 1314594-23-4 |
| 分子式 | C23H21N5 |
| 分子量 | 367.45 |
| 溶解度 | DMSO : 125 mg/mL (340.18 mM; ultrasonic and warming and heat to 60℃) |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | PKR-IN-C51(compound 51) is an ATP-competitive double-stranded RNA-activated protein kinase (PKR) inhibitor with an IC50 of 9 μM. PKR-IN-C51 inhibits intracellular PKR activation in a dose-dependent manner in primary mouse macrophages[1]. [1]. Ruslana Bryk, et al. Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4108-14. |
