(Rac)-CFT7455 是一种 Ikaros/Aiolos 降解剂，通过泛素蛋白酶体途径起作用，对 NCIH929.1 细胞的 GI50 为 0.05 nM。(Rac)-CFT7455 是具有抗癌活性的 CFT7455 的外消旋异构体。
| Cas No. | 2504233-68-3 |
| 分子式 | C28H27N3O4 |
| 分子量 | 469.53 |
| 溶解度 | DMSO : 62.5 mg/mL (133.11 mM; ultrasonic and warming and heat to 60°C) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | (Rac)-CFT7455 is a zinc finger transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) degrader, acting via the ubiquitin proteasome pathway, with a GI50 of 0.05 nM for NCIH929.1 cells. (Rac)-CFT7455 is the racemic isomer of CFT7455 which is a IKZF1/IKZF3 degrader with anticancer activity[1][2]. [1]. David Proia et al. Advantageous therapies for disorders mediated by ikaros or aiolos. WO2022032132A1 (compound 5)
[2]. James A. Henderson, et al. Abstract LB007: CFT7455: A novel, IKZF1/3 degrader that demonstrates potent tumor regression in IMiD-resistant multiple myeloma (MM) xenograft models. Cancer Res (2021) 81 (13_Supplement): LB007. |
