TDI-011536 是一种有效的 Lats 激酶抑制剂，能中断 Hippo-Yap 的信号传导，并可启动受损心肌细胞的增殖。TDI-011536 可用于研究器官的保护和再生。
| Cas No. | 2687970-96-1 |
| 分子式 | C19H16N4O2S |
| 分子量 | 364.42 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | TDI-011536 is a potentLats kinaseinhibitor, interruptsHippo-Yapsignaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration[1]. TDI-011536 (3 µM; 24 h) reduces Yap phosphorylation and (3 µM; 5 days) induces proliferation of MÜller glia in human retinal organoids[1]. Cell Proliferation Assay[1] | Cell Line: | human retinal organoids | | Concentration: | 3 µM | | Incubation Time: | 24 h, 5 days | | Result: | Supressed Yap phosphorylation and promoted MÜller glia proliferation. |
TDI-011536 (200 mg/kg; i.p.; once) provides over 4 h of Lats inhibition in the liver, heart, and skin and reduces the amount of pYap for at least 4 h after injection in all three organs[1].
TDI-011536 (100 mg/kg; i.p.; once daily for 2 or 3 days) shows proliferative effect on cardiomyocytes[1]. | Animal Model: | Living mice (immunoblot analysis of the heart, liver, and skin immediately after injection)[1]. | | Dosage: | 200 mg/kg | | Administration: | Intraperitoneal injections; once. | | Result: | Reduced the amount of pYap for at least 4 h after injection in all three organs and the levels returned to control values within a day. |
| Animal Model: | Male 8-week-old mice (cryolesion model)[1]. | | Dosage: | 100 mg/kg | | Administration: | Intraperitoneal injections; once daily for 2 or 3 days. | | Result: | Promoted cardiomyocytes proliferation. |
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