基因名：
Cdnf
产品别名：
9330140G23； Armetl1； Cdnf； cerebral dopamine neurotrophic factor； cerebral dopamine neurotrophic factor； cerebral dopamine neurotrophic factor； ARMET-like protein 1； arginine-rich, mutated in early stage tumors-like 1； conserved dopamine neurotrophic factor； 脑多巴胺神经营养因子； 脑多巴胺神经营养因子(CDNF)； 脑多巴胺神经营养因子(CDNF)真核蛋白；
背景信息：
erebral Dopamine Neurotrophic Factor (CDNF), also known as ARMETL1 (ARMET-like protein 1), is a secreted protein with eight conserved cysteine residues.It is belongs to the ARMET family. CDNF/ARMETL1 is a evolutionary conserved protein which can protect and restore the function of dopaminergic neurons in the rat model of Parkinson's disease, suggesting that CDNF might be beneficial for the treatment of Parkinson's disease. CDNF is widely expressed in neurons in several brain regions including cerebral cortex, hippocampus, substantia nigra, striatum and cerebellum. Human CDNF is glycosylated and secreted from transiently transfected cells. CDNF promotes the survival, growth, and function of dopamine-specific neurons and is expressed in brain regions that undergo cocaine-induced neuroplasticity.
