基因名：
TIGIT
产品别名：
VSIG9； VSTM3； WUCAM； TIGIT； T cell immunoreceptor with Ig and ITIM domains； T cell immunoreceptor with Ig and ITIM domains； T-cell immunoreceptor with Ig and ITIM domains； V-set and immunoglobulin domain containing 9； V-set and immunoglobulin domain-containing protein 9； V-set and transmembrane domain containing 3； V-set and transmembrane domain-containing protein 3； VSIG9, VSTM3； Washington University cell adhesion molecule； Ig和ITIM域蛋白T-细胞免疫受体(TIGIT)； Ig和ITIM域蛋白T-细胞免疫受体(TIGIT)真核蛋白； TIGIT蛋白；
背景信息：
T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the CD28 family within the Ig superfamily of proteins. TIGIT is expressed on NK cells and subsets of activated, memory and regulatory T cells, and particularly on follicular helper T cells within secondary lymphoid organs. It binds to CD155 and Nectin-2 that appear on dendritic cells (DC) and endothelium. Ligation of TIGIT on T cells down-regulates TCR-mediated activation and subsequent proliferation, while NK cell TIGIT ligation blocks NK cell cytotoxicity. Through CD155 and Nectin-2, which also interact with DNAM-1/CD226 and CD96/Tactile, TIGIT is part of an interacting network of Ig superfamily members that may augment or oppose each other. In particular, TIGIT binding to CD155 can antagonize the effects of DNAM1.
