基因名：
CLEC12A
产品别名：
CD371； CLL-1； CLL1； DCAL-2； MICL； CLEC12A； C-type lectin domain family 12 member A； C-type lectin domain family 12 member A； C-type lectin domain family 12 member A； C-type lectin protein CLL-1； C-type lectin-like molecule-1； dendritic cell-associated lectin 2； myeloid inhibitory C-type lectin-like receptor； C型凝集素结构域家族12成员A；
背景信息：
The C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily consists of a variety of proteins that share a common protein fold and have diverse functions, including cell-cell signaling, cell adhesion, glycoprotein turnover and immune responses. CLEC-12A (C-type lectin domain family 12, member A), also known as CLL1, MICL, CLL-1 or DCAL-2, is a 275 amino acid single-pass type II membrane protein that contains one C-type lectin domain and belongs to the CTL/CTLD superfamily. Existing as multiple alternatively spliced isoforms that are expressed in neutrophils, eosinophils, monocytes and dendritic cells, CLEC-12A functions as a cell surface receptor that acts as a negative regulator of granulocyte and monocyte function and, via this activity, modulates signaling cascades. CLEC-12A is highly subject to post-translational glycosylation at its N-terminus and may also exist as a homodimer.
