基因名：
MARCHF3
产品别名：
MARCH-III； MARCH3； RNF173； MARCHF3； membrane associated ring-CH-type finger 3； membrane associated ring-CH-type finger 3； E3 ubiquitin-protein ligase MARCHF3； E3 ubiquitin-protein ligase MARCH3； RING finger protein 173； RING-type E3 ubiquitin transferase MARCH3； RING-type E3 ubiquitin transferase MARCHF3； membrane associated ring finger 3； membrane-associated RING-CH protein III； membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase； 膜相关环指蛋白3；
背景信息：
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). MARCH3 (membrane-associated ring finger (C3HC4) 3), also known as RNF173, is a 253 amino acid multi-pass membrane protein that localizes to cytoplasmic vesicles and early endosomes and contains one RING-CH-type zinc finger. Involved in the pathway of protein modification, MARCH3 functions as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and is thought to be involved in endosomal trafficking events.
