基因名:
Cdca2
产品别名:
2610311M19Rik; AI586158; Cdca2; cell division cycle associated 2; cell division cycle associated 2; cell division cycle-associated protein 2; 细胞分裂周期蛋白2;
背景信息:
CDCA2 is a regulator of chromosome structure during mitosis. CDCA2 forms an essential complex with protein phosphatase PP1-gamma subunit 1 (PPP1CC) and is required for the recruitment of PP1 to chromatin. Knockdown of CDCA2 by RNAi causes large-scale cell death by apoptosis, as does overexpression of a dominant-negative mutant of the protein.