基因名：
BAGE2
产品别名：
CT2.2； BAGE2； BAGE family member 2, pseudogene； BAGE family member 2, pseudogene； B melanoma antigen family member 2； BAGE family member 2； cancer/testis antigen 2.2； cancer/testis antigen family 2, member 2； histone-lysine N-methyltransferase 2C； 肿瘤/睾丸抗原2.2/睾丸抗原2.3；
背景信息：
Members of the BAGE gene family encode antigens that are recognized by cytotoxic T lymphocytes and are also known as CT (cancer/testis) antigens. Generated by juxtacentromeric shuffling of the MLL3 gene, the ancestral BAGE gene was expanded by acrocentric exchanges and/or juxtacentromeric movements.Generally, BAGE proteins are silent in all normal tissues with the exception of testis. BAGE2 and BAGE 3 (B melanoma antigen 2 and 3, respectively), also known as Cancer/testis antigen 2.2 and 2.3 (respectively), are 109 amino acid secreted proteins that are expressed in 22% of melanomas, lung and bladder carcinomas, and are also expressed in normal testis tissue. Like the genes encoding MAGE proteins, BAGE genes are most likely silenced by DNA methylation and/or chromatin compaction in normal tissues other than testis.
