基因名：
Marchf8
产品别名：
1300017E09Rik； MARCH-VIII； March8； Mir； Marchf8； membrane associated ring-CH-type finger 8； membrane associated ring-CH-type finger 8； E3 ubiquitin-protein ligase MARCHF8； E3 ubiquitin-protein ligase MARCH8； RING-type E3 ubiquitin transferase MARCH8； RING-type E3 ubiquitin transferase MARCHF8； c-mir, cellular modulator of immune recognition； cellular modulator of immune recognition； membrane-associated RING finger protein 8； membrane-associated RING-CH protein VIII； membrane-associated ring finger (C3HC4) 8； 膜相关环指蛋白8；
背景信息：
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. MARCH8 (membrane-associated ring finger (C3HC4) 8), also known as MIR or RNF178 (RING finger protein 178), is a 291 amino acid multi-pass membrane protein that localizes to vesicle membranes and contains one RING-CH-type zinc finger. Expressed in a variety of tissues, including immature dendritic cells, MARCH8 functions as an E3 ubiquitin ligase that is thought to regulate immune responses by promoting the ubiquitination and subsequent degradation of target proteins, such as B7-2 and CD71.
