基因名：
Rnf128
产品别名：
1300002C13Rik； AI987883； GRAIL； Greul1； Rnf128； ring finger protein 128； ring finger protein 128； E3 ubiquitin-protein ligase RNF128； RING-type E3 ubiquitin transferase RNF128； gene related to anergy in lymphocytes protein； goliath-related E3 ubiquitin-protein ligase 1； 环指蛋白128； 环指蛋白128(RNF128)；
背景信息：
The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
