基因名:
Grtp1
产品别名:
5430401C05Rik; C81211; Tbc1d6; Grtp1; GH regulated TBC protein 1; GH regulated TBC protein 1; growth hormone-regulated TBC protein 1; TBC1 domain family member 6; 生长激素调节TBC蛋白1;
背景信息:
GRTP1 is a 336 amino acid protein with expression modulated by growth hormone. The TBC1 domain of GRTP1 is a region that is notably conserved among GTPase-activating proteins, which characteristically play a role in the cell cycle and mitosis coordination. Interestingly, expression of GRTP1 is significantly upregulated in post-puberty testis and then maintained in the adult, suggesting that the germ cell may be the major site of GRTP1 function. There are two isoforms of GRTP1, which are a result of alternative splicing events.