基因名：
NFKBIZ
产品别名：
IKBZ； INAP； MAIL； NFKBIZ； NFKB inhibitor zeta； NFKB inhibitor zeta； NF-kappa-B inhibitor zeta； I-kappa-B-zeta； IL-1 inducible nuclear ankyrin-repeat protein； IkappaB-zeta； ikB-zeta； ikappaBzeta； molecule possessing ankyrin repeats induced by lipopolysaccharide； nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta； KB抑制蛋白激酶Ζ； 核因子κB抑制因子ζ(IkBz)；
背景信息：
Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis.
