基因名：
IFIH1
产品别名：
AGS7； Hlcd； IDDM19； IMD95； MDA-5； MDA5； RLR-2； SGMRT1； IFIH1； interferon induced with helicase C domain 1； interferon induced with helicase C domain 1； interferon-induced helicase C domain-containing protein 1； CADM-140 autoantigen； DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide； RIG-I-like receptor 2； RNA helicase-DEAD box protein 116； clinically amyopathic dermatomyositis autoantigen 140 kDa； helicard； helicase with 2 CARD domains； melanoma differentiation-associated gene 5； melanoma differentiation-associated protein 5； murabutide down-regulated protein； 含干扰素诱导解旋酶C域蛋白1(IFIH1)； 黑色素瘤分化相关蛋白5；
背景信息：
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation. Genetic variation in this gene is associated with diabetes mellitus insulin-dependent type 19. [provided by RefSeq, Jul 2012]
