基因名：
ELAC2
产品别名：
COXPD17； ELC2； HPC2； ELAC2； elaC ribonuclease Z 2； elaC ribonuclease Z 2； zinc phosphodiesterase ELAC protein 2； RNase Z 2； elaC homolog 2； elaC homolog protein 2； elaC-like protein 2； heredity prostate cancer protein 2； putative prostate cancer susceptibility protein HPC2/ELAC2； ribonuclease Z 2； tRNA 3 endonuclease 2； tRNase Z (long form)； tRNase Z 2； 遗传性前列腺癌蛋白2；
背景信息：
ELAC2 is a zinc phosphodiesterase which displays some tRNA 3' processing endonuclease activity. It is thought to be involved in tRNA maturation, acting by removing a 3' trailer from precursor tRNA. ELAC2 also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. A number of allelic variants have been investigated in hereditary prostate cancer.
