基因名:
HAMP
产品别名:
HEPC; HFE2B; LEAP1; PLTR; HAMP; hepcidin antimicrobial peptide; hepcidin antimicrobial peptide; hepcidin; hepcidin preproprotein; liver-expressed antimicrobial peptide 1; putative liver tumor regressor; 铁调素(Hepc); 铁调素(Hepc)真核蛋白; 铁调节蛋白/铁调素; 铁调节蛋白25;
背景信息:
Hepcidin(HAMP)is a secreted protein that belongs to the hepcidin family.It is expressed in liver, heart and brain. It is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta sheet structures.