基因名：
USP28
产品别名：
USP28； ubiquitin specific peptidase 28； ubiquitin specific peptidase 28； ubiquitin carboxyl-terminal hydrolase 28； deubiquitinating enzyme 28； ubiquitin thioesterase 28； ubiquitin thiolesterase 28； ubiquitin-specific-processing protease 28； 泛素特异性蛋白酶28；
背景信息：
Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus.
