基因名：
RNF20
产品别名：
BRE1； BRE1A； hBRE1； RNF20； ring finger protein 20； ring finger protein 20； E3 ubiquitin-protein ligase BRE1A； BRE1 E3 ubiquitin ligase homolog； RING-type E3 ubiquitin transferase BRE1A； homolog of S. cerevisiae BRE1； 环指蛋白20；
背景信息：
RNF20 is an E3 ubiquitin ligase protein that mediates monoubiquitination of histone H2B and the methylation of histone H3. It forms a ubiquitin ligase complex in cooperation with the E2 enzyme UBE2E1/UBCH6. It thereby plays a central role in histone code and gene regulation. It is required for transcriptional activation of Hox genes. It is recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator.
