基因名：
Pals1
产品别名：
3830420B02Rik； AI255216； AI644496； Mpp5； Pals1； protein associated with LIN7 1, MAGUK family member； protein associated with LIN7 1, MAGUK family member； protein PALS1； MAGUK p55 subfamily member 5； membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 5)； membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)； protein associated with Lin-7 1； 棕榈酰化膜蛋白5； 棕榈酰化膜蛋白5(MPP5)；
背景信息：
Two highly conserved complexes are responsible for the assembly of tight junctions, the Crumbs-Pals1-Patj complex and the Cdc42-Par6-Par3-aPKC complex. Tight junctions assist in the formation of polarity in the epithelia by establishing a barrier to separate apical and basolateral membranes. Pals1, importantly, mediates interaction between the two complexes via interaction with Par6. Loss of Pals1 function results in delayed polarization, decreased transepithelial electrical resistance and an inability to form lumenal cysts. Because tumors exhibit perturbations in epithelial polarity, Pals1 presents a new potential target in the study of carcinogenesis.
