基因名：
PINX1
产品别名：
Gno1； LPTL； LPTS； Pxr1； PINX1； PIN2 (TERF1) interacting telomerase inhibitor 1； PIN2 (TERF1) interacting telomerase inhibitor 1； PIN2/TERF1-interacting telomerase inhibitor 1； 67-11-3 protein； PIN2-interacting protein 1； TRF1-interacting protein 1； hepatocellular carcinoma-related putative tumor suppressor； liver-related putative tumor suppressor； pin2-interacting protein X1； protein 67-11-3； 端粒酶抑制因子PinX-1；
背景信息：
PINX1 is a ubiquitously expressed protein that localizes to nucleoli and telomere speckles. PINX1 contains one G-patch domain and one telomeric inhibiting domain (TID) at its C-terminus. PINX1 interacts with the telomere protein TRF1 and the telomerase reverse transcriptase TERT. The TID domain of PINX1 specifically interacts with TERT and functions to inhibit its activity, thus participating in the regulation of telomerase activity. Overexpression of PINX1 leads to shortened telomeres, further supporting an inhibitory role of PINX1 on telomerase activity. The depletion of PINX1 significantly increases telomerase activity and may lead to tumorigenicity of cancer cells. This suggests that PINX1 acts as a tumor suppressor and can inhibit cell proliferation. In addition, PINX1 is involved in nucleolar RNA maturation.
