基因名:
BPNT2
产品别名:
GPAPP; IMP 3; IMP-3; IMPA3; IMPAD1; BPNT2; 3'(2'), 5'-bisphosphate nucleotidase 2; 3'(2'), 5'-bisphosphate nucleotidase 2; Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase; Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase; IMPase 3; golgi-resident PAP phosphatase; golgi-resident nucleotide phosphatase; inositol monophosphatase domain containing 1; inositol monophosphatase domain-containing protein 1; inositol-1(or 4)-monophosphatase 3; myo-inositol monophosphatase A3; phosphoadenosine phosphate 3'-nucleotidase; 肌醇单磷酸酶IMPA3;
背景信息:
IMPAD1 protein (IMPA3, gPAPP or IMPase 3) belongs to the inositol monophosphatase family. It is found in Purkinje cells, brain stem, lung and chondrocytes. Mouse IMPAD1 gene encodes a type II transmembrane Golgi-embedded glycoprotein with 356 amino acid residues which generates a 306 amino acid residues mature protein after processing. It is expressed in embryo, and in theory may catalyze myo-inositol monophosphate to myo-inositol. Free myo-inositol is used to generate inositol phospholipid, an essential component of intracellular signaling pathways that mobilize calcium. Mouse IMPAD1 exhibits 91% sequence identity with the human homologue.