基因名：
Fam3b
产品别名：
2-21； 9030624C24Rik； D16Jhu19e； ORF9； Pander； Fam3b； FAM3 metabolism regulating signaling molecule B； FAM3 metabolism regulating signaling molecule B； protein FAM3B； cytokine-like protein 2-21； family with sequence similarity 3, member B； pancreatic-derived factor； 序列相似家族3成员B(FAM3B)； 胰腺衍生因子；
背景信息：
FAM3B, also known as Pancreatic-derived factor (PANDER), is an islet-specific secreted cytokine specifically expressed at high levels in the islets of Langerhans of the endocrine pancreas. FAM3B can induce apoptosis of alpha and beta cells in a dose- and time-dependent manner. Previous studies showed that FAM3B regulates glucose and lipid metabolism through interaction with liver and endocrine pancreas. FAM3B silencing activates both extrinsic and intrinsic apoptotic pathways. In general, silencing FAM3B promoted p53 phosphorylation and induced p53 accumulation by decreasing Mdm2 expression, which resulted in apoptotic cell death.
