基因名：
GHRL
产品别名：
MTLRP； GHRL； ghrelin and obestatin prepropeptide； ghrelin and obestatin prepropeptide； appetite-regulating hormone； In2c-preproghrelin； ghrelin, growth hormone secretagogue receptor ligand； ghrelin/obestatin preprohormone； ghrelin/obestatin prepropeptide； growth hormone-releasing peptide； motilin-related peptide； prepro-appetite regulatory hormone； preproghrelin； 脑肠肽； 辛酰基化脑肠肽； 饥饿素(GHRL)； 饥饿素/肥胖抑制素前激素原(GHRL)；
背景信息：
This gene encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release. Obestatin was initially reported to be an endogenous ligand for the orphan G protein-coupled receptor GPR39 and was involved in satiety and decreased food intake; however, these findings are controversial. Recent reports show that obestatin is involved in inhibiting thirst and anxiety, improving memory, regulating sleep, affecting cell proliferation, and increasing the secretion of pancreatic juice enzymes. Alternative promoters and alternative splicing result in multiple transcript variants, some of which encode different protein isoforms and some of which do not encode a protein but may regulate the ghrelin-obestatin preproprotein expression. In addition, antisense transcripts for this gene have been identified and may also function in regulation of the ghrelin-obestatin preproprotein expression. [provided by RefSeq, Oct 2008].
