基因名：
MARCHF2
产品别名：
HSPC240； MARCH-II； MARCH2； RNF172； MARCHF2； membrane associated ring-CH-type finger 2； membrane associated ring-CH-type finger 2； E3 ubiquitin-protein ligase MARCHF2； E3 ubiquitin-protein ligase MARCH2； RING finger protein 172； RING-type E3 ubiquitin transferase MARCH2； RING-type E3 ubiquitin transferase MARCHF2； membrane associated ring finger 2； membrane-associated RING finger protein 2； membrane-associated RING-CH protein II； membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase； 膜相关环指蛋白2；
背景信息：
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). MARCH2 (membrane-associated ring finger (C3HC4) 2), also known as RNF172 or HSPC240, is a 246 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum and contains one RING-CH-type zinc finger. Expressed in a variety of tissues, MARCH2 functions as an E3 ubiquitin-protein ligase that is thought to mediate the ubiquitination and subsequent degradation of CD71 and B7-2 and may be involved in endosomal protein trafficking.
